Koblin B A, Hessol N A, Zauber A G, Taylor P E, Buchbinder S P, Katz M H, Stevens C E
Wolf Szmuness Laboratory of Epidemiology, New York Blood Center, New York, USA.
Am J Epidemiol. 1996 Nov 15;144(10):916-23. doi: 10.1093/oxfordjournals.aje.a008861.
Several studies have shown that human immunodeficiency virus type 1 (HIV-1) is associated with an increase in the incidence of Kaposi's sarcoma and non-Hodgkin's lymphoma among homosexual men. The role of HIV-1 in increasing the incidence of other malignancies is more controversial. The incidence of non-Kaposi's sarcoma cancer was examined from 1978 to 1990 among 15,565 homosexual men who participated in studies of hepatitis B virus infection in the late 1970s in New York City, New York, and San Francisco, California. The standardized incidence ratio (SIR) for all cancers was 1.6 (95% confidence interval (CI) 1.4-1.8). Excesses were observed for non-Hodgkin's lymphoma (SIR = 12.7; 95% CI 11.0-14.6). Hodgkin's disease (SIR = 2.5; 95% CI 1.5-3.9), and anal cancer (SIR = 24.2 95% CI 13.5-39.9). As seen with non-Hodgkin's lymphoma, a cancer known to be associated with HIV-1. Hodgkin's disease incidence was significantly higher in more recent years compared with earlier years. No cases of Hodgkin's disease were found among HIV-1 antibody-negative men, and Hodgkin's disease was diagnosed near the time of initial acquired immunodeficiency syndrome diagnoses. Anal cancer incidence did not correlate with HIV-1 antibody status and did not tend to occur near the time of AIDS diagnoses. This study confirms the association of non-Hodgkin's lymphoma with HIV-1 infect on and suggests an association between Hodgkin's disease and HIV-1 infection. An excess in anal cancer was observed but did not appear to be associated with HIV-1 infection.
多项研究表明，1型人类免疫缺陷病毒（HIV-1）与男同性恋者中卡波西肉瘤和非霍奇金淋巴瘤发病率的增加有关。HIV-1在增加其他恶性肿瘤发病率方面的作用更具争议性。1978年至1990年期间，对15565名男同性恋者的非卡波西肉瘤癌症发病率进行了检查，这些男同性恋者于20世纪70年代末在纽约市、纽约州以及加利福尼亚州旧金山参与了乙肝病毒感染研究。所有癌症的标准化发病比（SIR）为1.6（95%置信区间（CI）1.4 - 1.8）。观察到非霍奇金淋巴瘤（SIR = 12.7；95% CI 11.0 - 14.6）、霍奇金病（SIR = 2.5；95% CI 1.5 - 3.9）和肛管癌（SIR = 24.2；95% CI 13.5 - 39.9）发病率过高。正如在已知与HIV-1相关的非霍奇金淋巴瘤中所见，近年来霍奇金病的发病率明显高于早年。在HIV-1抗体阴性的男性中未发现霍奇金病病例，且霍奇金病在初次获得性免疫缺陷综合征诊断时被确诊。肛管癌发病率与HIV-1抗体状态无关，且在艾滋病诊断时也没有发病倾向。这项研究证实了非霍奇金淋巴瘤与HIV-1感染之间的关联，并提示霍奇金病与HIV-1感染之间存在关联。观察到肛管癌发病率过高，但似乎与HIV-1感染无关。
