Litaker D G, Solomon G D, Genzen J R
Department of General Internal Medicine, Cleveland Clinic Foundation, OH 44195, USA.
Headache. 1996 Oct;36(9):538-41. doi: 10.1046/j.1526-4610.1996.3609538.x.
Although migraine headaches affect a large segment of the population, no objective measure of therapeutic success is currently available. Comparing visit frequency and associated costs of care before and after introduction of a new therapy represents an important surrogate measure of success.
One hundred four patients regularly attending a headache clinic for migraines at a tertiary care hospital were instructed in the use of a new abortive migraine therapy. Medical appointment and financial systems were searched retrospectively for visit frequency and associated patient care and institutional costs. The number of visits and mean costs 18 months before and after initiation of therapy were compared using the signed rank test and paired t-test, respectively.
The median number of visits made by study subjects to the headache clinic fell significantly following sumatriptan test dosing (P < 0.001). Prior to the new treatment, mean total patient care and institutional costs were $228.59 and $112.81 per person, respectively, and fell to $135.93 and $78.16 (P < 0.001) after therapy began.
These data suggest that many patients with migraine benefit from sumatriptan, seek medical attention in a headache clinic less often, and incur fewer costs following initiation of treatment with this drug.
尽管偏头痛影响着很大一部分人群,但目前尚无衡量治疗成功与否的客观指标。比较引入新疗法前后的就诊频率及相关护理费用是衡量成功与否的一项重要替代指标。
指导一家三级护理医院头痛门诊的104例偏头痛患者使用一种新的偏头痛缓解疗法。回顾性检索医疗预约和财务系统,以获取就诊频率及相关患者护理和机构成本。分别使用符号秩检验和配对t检验比较治疗开始前后18个月的就诊次数和平均成本。
舒马曲坦试验给药后,研究对象到头痛门诊的就诊次数中位数显著下降(P<0.001)。新治疗前,患者人均护理总成本和机构成本分别为228.59美元和112.81美元,治疗开始后降至135.93美元和78.16美元(P<0.001)。
这些数据表明,许多偏头痛患者从舒马曲坦治疗中获益,减少了到头痛门诊就诊的次数,且开始使用该药物治疗后费用降低。