使用碘-123-β-CIT-FP单光子发射计算机断层扫描（SPECT）和氟-18-FDOPA正电子发射断层扫描（PET）进行黑质纹状体多巴胺能成像比较
Comparative nigrostriatal dopaminergic imaging with iodine-123-beta CIT-FP/SPECT and fluorine-18-FDOPA/PET.
作者信息
Ishikawa T, Dhawan V, Kazumata K, Chaly T, Mandel F, Neumeyer J, Margouleff C, Babchyck B, Zanzi I, Eidelberg D
机构信息
Department of Neurology, North Shore University Hospital, Manhasset, New York, USA.
出版信息
J Nucl Med. 1996 Nov;37(11):1760-5.
UNLABELLED
SPECT imaging of the dopamine transporter is now an alternative to PET in the quantification of nigrostriatal dopaminergic function. We compared [123I] beta CIT-FP/SPECT and [18F]FDOPA/PET in the assessment of nigrostriatal dopaminergic function in Parkinson's disease (PD) and normal aging.
METHODS
We studied 12 mildly affected PD patients (mean age: 61.0 +/- 13.2 yr; H&Y Stage I-II) with both [123I] beta CIT-FP and [18F]FDOPA. Fifteen normal volunteers (mean age: 45.5 +/- 22.1 yr) served as controls for both tracers. We measured the striato-occipital ratio (SOR) for both tracers at approximately 100 min postinjection.
RESULTS
We found a highly significant correlation between SOR measures obtained for both tracers (r = 0.79, p < 0.0001). In normal volunteers a significant age-related decline in striatal uptake was noted with [123I] beta CIT-FP (r = -0.56, p < 0.04) but not with [18F]FDOPA. SOR values for both tracers discriminated PD patients from controls with comparable accuracy (F[1,25] = 52.1 and 53.0, p < 0.0001 for [123I] beta CIT-FP and [18F]FDOPA, respectively). UPDRS motor ratings correlated with SOR values obtained by both imaging techniques (r = -0.69 and -0.60, p < 0.04 for [123I] beta CIT-FP and [18F]FDOPA, respectively).
CONCLUSION
These results indicate that [123I] beta CIT-FP/SPECT can provide quantitative descriptors of presynaptic dopaminergic function comparable to those obtained with [18F]FDOPA/PET.
未标注
多巴胺转运体的单光子发射计算机断层扫描（SPECT）成像现在是正电子发射断层扫描（PET）在黑质纹状体多巴胺能功能定量方面的一种替代方法。我们比较了[123I]β-CIT-FP/SPECT和[18F]FDOPA/PET在评估帕金森病（PD）和正常衰老过程中的黑质纹状体多巴胺能功能。
方法
我们研究了12例轻度受影响的PD患者（平均年龄：61.0±13.2岁；H&Y分期I-II期），对其同时使用[123I]β-CIT-FP和[18F]FDOPA进行检查。15名正常志愿者（平均年龄：45.5±22.1岁）作为两种示踪剂的对照。我们在注射后约100分钟测量了两种示踪剂的纹状体-枕叶比值（SOR）。
结果
我们发现两种示踪剂获得的SOR测量值之间存在高度显著的相关性（r = 0.79，p < 0.0001）。在正常志愿者中，使用[123I]β-CIT-FP时观察到纹状体摄取有显著的年龄相关性下降（r = -0.56，p < 0.04），而使用[18F]FDOPA时未观察到。两种示踪剂的SOR值以相当的准确性区分了PD患者和对照（对于[123I]β-CIT-FP和[18F]FDOPA，F[1,25]分别为52.1和53.0，p < 0.0001）。统一帕金森病评定量表（UPDRS）运动评分与两种成像技术获得的SOR值相关（对于[123I]β-CIT-FP和[18F]FDOPA，r分别为-0.69和-0.60，p < 0.04）。
结论
这些结果表明，[123I]β-CIT-FP/SPECT可以提供与[18F]FDOPA/PET获得的结果相当的突触前多巴胺能功能定量描述。
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