Swanson H, Hughes P A, Messer S A, Lepow M L, Pfaller M A
Department of Pediatric Infectious Disease, Albany Medical Center, New York 12203, USA.
J Pediatr. 1996 Nov;129(5):688-94. doi: 10.1016/s0022-3476(96)70151-8.
Fungal arthritis in pediatric patients is rare and is most often associated with hematogenous spread to the affected joint. It is generally seen concomitant with, or shortly after, fungemia. We report a case of an immunocompetent patient in whom candidal arthritis developed 1 year after initial fungemia. The initial candidiasis was considered to be adequately treated with amphotericin B. The Candida isolates from the neonatal fungemia and subsequent arthritis were the some as identified by electrophoretic karyotype, restriction fragment length polymorphism analysis, and antifungal susceptibility testing. Pediatric candidal fungemia, arthritis, and their treatments are discussed.
儿童真菌性关节炎较为罕见，通常与血源性播散至受累关节有关。一般在真菌血症出现时或之后不久即可见到。我们报告一例免疫功能正常的患者，在初次真菌血症发生1年后出现念珠菌性关节炎。最初的念珠菌病被认为用两性霉素B治疗得当。通过电泳核型分析、限制性片段长度多态性分析和抗真菌药敏试验鉴定，新生儿真菌血症及随后关节炎所分离出的念珠菌是相同的。本文讨论了儿童念珠菌性真菌血症、关节炎及其治疗方法。
