Le Calloch Ronan, Ianotto Jean-Christophe, Guillerm Gaëlle, Tonnelier Jean Marie
Department of Hématologie, Chru Brest, Brest, France.
BMJ Case Rep. 2013 Aug 13;2013:bcr2013008902. doi: 10.1136/bcr-2013-008902.
Aplastic anaemia is a rare and serious disease characterised by severe immunosuppression due to prolonged neutropenia and the use of immunosuppressants such as corticosteroids, cyclosporine and antithymocyte globulin. Candida species are pathogens of low virulence colonising the skin and the digestive tract of many healthy individuals. Nonetheless, the incidence of invasive candidal infection is increasing. The widespread use of central intravascular catheters, invasive procedures, broad-spectrum antibiotics and immunosuppresion predisposes patients to these infections. Eye, skin, cardiac, liver, spleen and brain infection are the most common sites of invasive candidiasis. Bone and joint infections are less frequent and Candida hip septic arthritis is extremely rare. We present here a patient treated for aplastic anaemia, who developed fungal arthritis of the hip and systemic candidaemia.
再生障碍性贫血是一种罕见且严重的疾病，其特征是由于长期中性粒细胞减少以及使用皮质类固醇、环孢素和抗胸腺细胞球蛋白等免疫抑制剂导致严重免疫抑制。念珠菌属是低毒力病原体，定植于许多健康个体的皮肤和消化道。尽管如此，侵袭性念珠菌感染的发生率正在上升。中心血管内导管的广泛使用、侵入性操作、广谱抗生素和免疫抑制使患者易患这些感染。眼部、皮肤、心脏、肝脏、脾脏和脑部感染是侵袭性念珠菌病最常见的部位。骨和关节感染较少见，念珠菌性髋部化脓性关节炎极为罕见。我们在此报告一名接受再生障碍性贫血治疗的患者，该患者发生了髋部真菌性关节炎和全身性念珠菌血症。
