Tugnoli V, Tosi M R, Barbarella G, Bertoluzza A, Ricci R, Trevisan C
Dipartimento di Biochimica G. Moruzzi, Università di Bologna, Italy.
Anticancer Res. 1996 Sep-Oct;16(5A):2891-9.
Localized in vivo 1H MR spectra of four patients with brain tumors and in vitro multinuclear (1H, 13C and 31P) MR characterization of water soluble and lipid components of the same tumors after surgical removal are reported herein. The in vivo spectra of the neoplastic regions of all patients showed N-Acetyl-Aspartate/Choline (NAA/Cho), Choline/Creatine (Cho/Cr) and N-Acetyl-Aspartate/Creatine (NAA/Cr) metabolite ratios markedly different from those of the controlateral healthy tissue. In vitro 1H MR measurements allowed for the identification of a much larger number of metabolites than those measured in vivo. Indeed, well resolved 1H, 13C and 31P MR spectra were obtained for water soluble and lipid components in all cases. Our data confirm that some metabolites observed in vitro could be specific markers of brain tumors.
本文报道了4例脑肿瘤患者的局部体内1H磁共振波谱，以及手术切除后同一肿瘤的水溶性和脂质成分的体外多核（1H、13C和31P）磁共振特征。所有患者肿瘤区域的体内波谱显示，N-乙酰天门冬氨酸/胆碱（NAA/Cho）、胆碱/肌酸（Cho/Cr）和N-乙酰天门冬氨酸/肌酸（NAA/Cr）代谢物比率与对侧健康组织明显不同。体外1H磁共振测量能够识别出比体内测量更多的代谢物。事实上，在所有情况下，水溶性和脂质成分均获得了分辨良好的1H、13C和31P磁共振波谱。我们的数据证实，体外观察到的一些代谢物可能是脑肿瘤的特异性标志物。
