Lau G
Department of Forensic Medicine, Institute of Science and Forensic Medicine, Singapore, Republic of Singapore.
Med Sci Law. 1996 Jul;36(3):263-5. doi: 10.1177/002580249603600314.
A patient with acute lymphoblastic leukaemia was mistakenly given vincristine intraventricularly, as part of an intensified course of chemotherapy. Despite a CNS washout and supportive treatment, the patient developed progressive ascending paralysis, gradually lapsed into coma and died some 10 days later. Autopsy and post-mortem histological examination showed evidence of brain death caused by florid encephalomyelitis, apparently induced by the intraventricular administration of vincristine.
一名急性淋巴细胞白血病患者在强化化疗过程中被误将长春新碱注入脑室内。尽管进行了中枢神经系统冲洗和支持治疗，患者仍出现进行性上升性麻痹，逐渐陷入昏迷，并在约10天后死亡。尸检和死后组织学检查显示，由脑室内注射长春新碱明显诱发的急性脑脊髓炎导致了脑死亡。
