Shimizu E, Shirasawa H, Kodama K, Sato T, Simizu B
Department of Microbiology, School of Medicine, Chiba University, Japan.
Gene. 1996 Oct 17;176(1-2):45-8. doi: 10.1016/0378-1119(96)00206-5.
The myc proto-oncogene family plays an important role in the control of cellular growth and differentiation. Mxi1, one of the Max-associated proteins, has been known to have an antagonistic action on Myc activity. The mxi1 mRNA increased during growth inhibition and differentiation, and decreased with serum stimulation in mammal cell lines. We have also found an AAAAC polymorphic repeat in the 3' non-coding region of the human mxi1 cDNAs and a difference between the mxi1 mRNA half-lives in some different cell lines.
Myc原癌基因家族在细胞生长和分化的调控中发挥着重要作用。Mxi1是与Max相关的蛋白之一，已知它对Myc活性具有拮抗作用。在哺乳动物细胞系中，mxi1 mRNA在生长抑制和分化过程中增加，而在血清刺激下减少。我们还在人类mxi1 cDNA的3'非编码区发现了一个AAAAC多态性重复序列，并且在一些不同的细胞系中mxi1 mRNA半衰期存在差异。
