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c-Myc target genes involved in cell growth, apoptosis, and metabolism.参与细胞生长、凋亡和代谢的c-Myc靶基因。
Mol Cell Biol. 1999 Jan;19(1):1-11. doi: 10.1128/MCB.19.1.1.
2
Transcriptional regulation. Flipping the Myc switch.转录调控。翻转Myc开关。
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3
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4
Myc/Max/Mad regulate the frequency but not the duration of productive cell cycles.Myc/Max/Mad调节有丝分裂细胞周期的频率而非持续时间。
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Taking myc to the max.将myc发挥到极致。
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本文引用的文献

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On the origin of cancer cells.论癌细胞的起源。
Science. 1956 Feb 24;123(3191):309-14. doi: 10.1126/science.123.3191.309.
2
myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome.Myc结构域在Myc家族蛋白中具有保守性，是通过蛋白酶体进行蛋白质降解的信号。
Mol Cell Biol. 1998 Oct;18(10):5961-9. doi: 10.1128/MCB.18.10.5961.
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Identification of c-MYC as a target of the APC pathway.鉴定c-MYC为APC通路的一个靶点。
Science. 1998 Sep 4;281(5382):1509-12. doi: 10.1126/science.281.5382.1509.
4
A matter of life and cell death.关乎生死与细胞凋亡之事。
Science. 1998 Aug 28;281(5381):1317-22. doi: 10.1126/science.281.5381.1317.
5
A Drosophila RNA helicase gene, pitchoune, is required for cell growth and proliferation and is a potential target of d-Myc.一种果蝇RNA解旋酶基因pitchoune，是细胞生长和增殖所必需的，并且是d-Myc的一个潜在靶点。
Development. 1998 Sep;125(18):3571-84. doi: 10.1242/dev.125.18.3571.
6
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.新型ATM相关蛋白TRRAP是c-Myc和E2F癌蛋白的重要辅助因子。
Cell. 1998 Aug 7;94(3):363-74. doi: 10.1016/s0092-8674(00)81479-8.
7
YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc.YY1可通过一种需要YY1与DNA结合的机制来抑制c-Myc功能，该机制既不依赖于YY1的反式激活结构域，也不依赖于其与c-Myc的直接相互作用。
Oncogene. 1998 Jul 30;17(4):511-20. doi: 10.1038/sj.onc.1201968.
8
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.通过ARF肿瘤抑制因子的Myc信号传导调节p53依赖的细胞凋亡和永生化。
Genes Dev. 1998 Aug 1;12(15):2424-33. doi: 10.1101/gad.12.15.2424.
9
Identification of a large Myc-binding protein that contains RCC1-like repeats.鉴定出一种含有类RCC1重复序列的大型Myc结合蛋白。
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9172-7. doi: 10.1073/pnas.95.16.9172.
10
Myc activates telomerase.Myc激活端粒酶。
Genes Dev. 1998 Jun 15;12(12):1769-74. doi: 10.1101/gad.12.12.1769.

c-Myc target genes involved in cell growth, apoptosis, and metabolism.

作者信息

Dang C V

机构信息

Department of Medicine, The Johns Hopkins Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

出版信息

Mol Cell Biol. 1999 Jan;19(1):1-11. doi: 10.1128/MCB.19.1.1.

DOI:10.1128/MCB.19.1.1
PMID:9858526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC83860/
Abstract
摘要