Zeitlin L, Whaley K J, Sanna P P, Moench T R, Bastidas R, De Logu A, Williamson R A, Burton D R, Cone R A
Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Virology. 1996 Nov 1;225(1):213-5. doi: 10.1006/viro.1996.0589.
A recombinant human anti-herpes simplex virus monoclonal IgG1, antibody and the corresponding Fab and F(ab')2 fragments were tested for efficacy in preventing vaginal transmission of HSV-2 infection in a well-established mouse model for genital herpes. IgG1, Fab, and F(ab')2 were approximately equally protective; vaginal delivery of 1-5 ng provided approximately 50% protection, and vaginal delivery of 400 ng completely protected mice from genital herpes infection (P < 0.001). These results suggest that topical applications of human monoclonal antibodies may be useful in developing new methods for preventing sexually transmitted disease.
在一个成熟的生殖器疱疹小鼠模型中，对一种重组人抗单纯疱疹病毒单克隆IgG1抗体以及相应的Fab和F(ab')2片段进行了预防HSV-2感染经阴道传播的功效测试。IgG1、Fab和F(ab')2的保护作用大致相同；经阴道给予1-5纳克可提供约50%的保护，经阴道给予400纳克可使小鼠完全免受生殖器疱疹感染（P<0.001）。这些结果表明，局部应用人单克隆抗体可能有助于开发预防性传播疾病的新方法。
