Moran T H, Carrigan T S, Schwartz G J, Ladenheim E E
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Behav Neurosci. 1996 Oct;110(5):1110-6.
The ability of dose combinations of cholecystokinin (CCK) and bombesin to inhibit liquid glucose (0.125 gm/ml) intake and affect microstructural components of ingestive behavior in rats was examined. Five minutes before access to the glucose solution, rats were injected with dose pairs of CCK and bombesin. Both CCK and bombesin inhibited intake in a dose-related fashion. The magnitude of the inhibition produced by dose combinations was never greater than the sum of the inhibitions produced by the individual doses. CCK and bombesin affected different microstructural components of ingestion. CCK reduced burst size and cluster size, whereas bombesin reduced burst number and cluster number. These effects of the 2 peptides were not altered by the presence of the other peptide. These results suggest that different mechanisms of action underlie the feeding inhibitory actions of the 2 peptides.
研究了胆囊收缩素（CCK）和蛙皮素的剂量组合抑制大鼠摄入液态葡萄糖（0.125克/毫升）以及影响摄食行为微观结构成分的能力。在给予葡萄糖溶液前5分钟，给大鼠注射CCK和蛙皮素的剂量组合。CCK和蛙皮素均以剂量相关的方式抑制摄入量。剂量组合产生的抑制程度从未超过各单独剂量产生的抑制作用之和。CCK和蛙皮素影响摄食的不同微观结构成分。CCK减少了突发量和簇集量，而蛙皮素减少了突发次数和簇集次数。两种肽的这些作用不会因另一种肽的存在而改变。这些结果表明，两种肽的摄食抑制作用存在不同的作用机制。
