Pelizza G, Nebuloni M, Ferrari P, Gallo G G
Farmaco Sci. 1977 Jul;32(7):471-81.
The antibiotic rifampicin shows polymorphism. Two crystalline forms, an amorphous form and four solvates (S I and S II from water; S III from tetrahydrofuran; S IV from carbon tetachloride) have been isolated and characterized by thermal analysis, infrared and X-ray powder spectroscopy. The functional I.R. bands have been interpreted as indicative of some structural features involved in the polymorphism: the intramolecular H-bonds between C23--OH and O=C--O--C25, C4--OH and O=C11, and C1--OH and O=C15. The relative physical stabilities of the various forms are reported.
抗生素利福平具有多晶型现象。已分离出两种晶型、一种无定形形式和四种溶剂化物（水合物S I和S II；四氢呋喃合物S III；四氯化碳合物S IV），并通过热分析、红外光谱和X射线粉末光谱对其进行了表征。功能性红外波段已被解释为表明多晶型现象中涉及的一些结构特征：C23-OH与O=C-O-C25、C4-OH与O=C11以及C1-OH与O=C15之间的分子内氢键。报道了各种形式的相对物理稳定性。
