Sobh M, Refaie A, El-Tantawy A E, Saad M, Said E, Arif S, El-Sherif A, Ghoneim M
Urology and Nephrology Center, University of Mansoura, Egypt.
Am J Nephrol. 1996;16(2):114-7. doi: 10.1159/000168981.
Neuromuscular status of amyloid and control groups of kidney transplant recipients was assessed through complete neurological examination, assay for serum levels of muscle enzymes (CPK and LDH), electromyography and nerve conduction velocity studies. Neuromyopathic findings were detected in both groups but without severe disabling clinical manifestations. These findings were more prominent in the amyloid group, evidenced by a more significant increase in polyphasicity detected by electromyography and longer prolongation of terminal latency measured in the median nerve. From this study, we concluded that amyloid kidney transplant recipients are more prone to neuromyopathy than the general kidney transplant population, which is mostly due to the amyloidosis itself and/or the colchicine therapy.
通过全面的神经学检查、检测血清肌肉酶水平（肌酸磷酸激酶和乳酸脱氢酶）、肌电图以及神经传导速度研究，对肾移植受者的淀粉样变组和对照组的神经肌肉状况进行了评估。两组均检测到神经肌肉病变，但无严重致残的临床表现。这些发现在淀粉样变组更为突出，肌电图检测到的多相波更显著增加以及正中神经测量的终末潜伏期延长更长证明了这一点。从这项研究中，我们得出结论，淀粉样变肾移植受者比一般肾移植人群更容易发生神经肌肉病变，这主要是由于淀粉样变性本身和/或秋水仙碱治疗。
