Garcia-Silva J, Velasco-Benito J A, Pena-Penabad C, Armijo M
Department of Dermatology, University Hospital, Salamanca, Spain.
Pediatr Dermatol. 1996 Jan-Feb;13(1):54-7. doi: 10.1111/j.1525-1470.1996.tb01190.x.
A 12-year-old girl had a lesion located on the upper part of the scalp that was clinically interpreted as a melanocytic nevus and corresponded histologically to a basal cell carcinoma. At age 2 years she had been diagnosed as having acute lymphoblastic leukemia L1, for which she was treated with systemic chemotherapy. She also received telecobalt therapy to the whole cranium for prophylaxis of meningeal leukosis. Having rejected other possible causes that can favor the appearance of basal cell carcinoma during childhood (basal cell nevus syndrome, nevus sebaceus, albinism, etc.), we believe that this case should be added to the five previously reported in the literature as basal cell carcinoma developing at an early age in cranial radiation portals with megavoltage radiotherapy. We draw attention to the need to explore radiated areas of skin as part of the long-term follow-up of these patients, and to the advisability of obtaining a biopsy from any persistent lesion in these areas.
一名12岁女孩头皮上部有一处病变，临床诊断为黑素细胞痣，组织学检查结果为基底细胞癌。她2岁时被诊断为急性淋巴细胞白血病L1型，接受了全身化疗。为预防脑膜白血病，她还接受了全颅钴远距离治疗。排除了其他可能导致儿童期出现基底细胞癌的原因（基底细胞痣综合征、皮脂腺痣、白化病等）后，我们认为该病例应加入文献中先前报道的5例，这些病例均为在接受兆伏放疗的颅脑放射野内早年发生的基底细胞癌。我们提请注意，作为这些患者长期随访的一部分，需要对放射过的皮肤区域进行检查，并且对于这些区域中任何持续存在的病变进行活检是可取的。
