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Effects of beraprost sodium and prostaglandin E1 on skin blood flow in diabetic rats and normal dogs.

作者信息

Ueno Y, Yamada N, Koike H, Nishio S

机构信息

Basic Research Laboratories, Toray Industries Inc., Kanagawa, Japan.

出版信息

Gen Pharmacol. 1996 Mar;27(2):333-5. doi: 10.1016/0306-3623(95)02007-1.

DOI:10.1016/0306-3623(95)02007-1
PMID:8919652
Abstract
  1. The present study was undertaken to compare the effects of beraprost sodium (BPS), a stable prostaglandin I2 analog, with prostaglandin E1 (PGE1) on the skin blood flow in anesthesized diabetic rats and anesthetized dogs. 2. In anesthetized diabetic rats, BPS, but not PGE1, caused a dose-dependent and significant increase in femoral skin blood flow. 3. In anesthetized dogs, PGE1 significantly increased femoral arterial blood flow than BPS. However, BPS significantly increased in-step skin blood flow than PGE1. 4. The above data suggest that BPS may be clinically useful for the treatment of circulatory insufficiency of lower extremities in diabetic patients.
摘要

相似文献

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Effects of beraprost sodium and prostaglandin E1 on skin blood flow in diabetic rats and normal dogs.
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General pharmacology of beraprost sodium. 2nd communication: effect on the autonomic, cardiovascular and gastrointestinal systems, and other effects.贝前列素钠的一般药理学。第二篇通讯：对自主神经系统、心血管系统和胃肠道系统的作用及其他作用。
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Evaluation of microangiopathy of the skin in patients with non-insulin-dependent diabetes mellitus by laser Doppler flowmetry; microvasodilatory responses to beraprost sodium.用激光多普勒血流仪评估非胰岛素依赖型糖尿病患者皮肤微血管病变；贝前列素钠的微血管舒张反应。
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