Battal M N, Hata Y, Matsuka K, Ito O, Matsuda H, Yoshida Y, Kawazoe T
Department of Plastic Surgery, Kagawa Medical School, Japan.
Burns. 1996 Nov;22(7):531-8. doi: 10.1016/0305-4179(96)00024-1.
Beraprost sodium is a chemically stable prostaglandin I2 analogue with antiplatelet and vasodilator actions. Burn injury causes thrombosis and vessel occlusion by increasing the blood viscosity and by thermal damage to the vascular network in the dermis. A vascular response also occurs in the uninjured dermis surrounding the site of injury. Diminished blood flow and spreading tissue oedema lead to progressive ischaemia and necrosis around the burn site (zone of stasis), with the final necrotic tissue area being larger than the initial one. If blood flow could be restored in the zone of stasis, secondary tissue damage would be minimized. In this study, we examined the effects of a prostaglandin I2 analogue, beraprost sodium (Procylin, Kaken Pharmaceutical Company, Tokyo, Japan) on burn injury in rats. Twenty male Sprague-Dawley rats weighing an average of 450 g were burned with a comb-shaped brass probe that produced a row of three burns measuring 10 x 30 mm each and two intervening unburned areas measuring 5 x 30 mm each. The rats were divided into two groups of 10 animals. One group received 0.015 mg of beraprost sodium intraperitoneally immediately after burn injury, while the control group received the same volume of saline. Skin blood flow was measured with a laser Doppler flowmeter, and the development of oedema as well as the area of necrotic tissue were also determined. The extent of skin necrosis and oedema were significantly reduced in the beraprost sodium-treated rats, and blood flow in the zone of stasis was increased. These findings demonstrate that prostaglandin I2 plays an important role in burn injury and that beraprost sodium can reduce secondary necrosis in the zone of stasis.
贝拉前列素钠是一种化学性质稳定的前列腺素I2类似物，具有抗血小板和血管舒张作用。烧伤会通过增加血液粘度以及对真皮层血管网络造成热损伤，从而导致血栓形成和血管阻塞。在损伤部位周围未受伤的真皮层也会发生血管反应。血流量减少和组织水肿扩散会导致烧伤部位周围（停滞区）逐渐出现缺血和坏死，最终坏死组织面积会大于初始面积。如果能够恢复停滞区的血流，继发性组织损伤将降至最低。在本研究中，我们研究了前列腺素I2类似物贝拉前列素钠（前列环素，日本东京嘉研制药公司）对大鼠烧伤的影响。20只平均体重为450克的雄性Sprague-Dawley大鼠，用梳状黄铜探针烧伤，该探针造成一排三处烧伤，每处烧伤面积为10×30毫米，以及两处中间未烧伤区域，每处面积为5×30毫米。大鼠被分为两组，每组10只。一组在烧伤后立即腹腔注射0.015毫克贝拉前列素钠，而对照组注射相同体积的生理盐水。用激光多普勒血流仪测量皮肤血流量，并测定水肿的发展情况以及坏死组织的面积。贝拉前列素钠治疗的大鼠皮肤坏死和水肿程度明显减轻，停滞区的血流量增加。这些发现表明前列腺素I2在烧伤中起重要作用，并且贝拉前列素钠可以减少停滞区的继发性坏死。
