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In vivo quantification of muscle damage in dogs after intramuscular administration of drugs.

作者信息

Aktas M, Vinclair P, Lefebvre H P, Toutain P L, Braun J P

机构信息

Département de Physiopathologie, URA-INRA Physiopathologie et Toxicologie Expérimentales, Toulouse, France.

出版信息

Br Vet J. 1995 Mar-Apr;151(2):189-96. doi: 10.1016/s0007-1935(95)80010-7.

DOI:10.1016/s0007-1935(95)80010-7
PMID:8920114
Abstract

Intramuscular injections of a vitamin B preparation, imidocarb, imidocarb+lidocaine, and a preparation of salts of fatty acids produced significant increases in plasma creatine kinase activity in groups of five to six dogs. Activities peaked between 3 and 8 h, and were as high as 23 times base values with the fatty acid salts preparation. Quantification of the equivalent muscle damage gave means of 0.04, 0.25, 0.23 and 0.30 g kg-1 body weight, respectively, for each of the above preparations.

摘要

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