Jardine J E, Nesbit J W
Department of Pathology, University of Pretoria, Onderstepoort, South Africa.
J Comp Pathol. 1996 Feb;114(2):193-8. doi: 10.1016/s0021-9975(96)80008-9.
A large abdominal mass in a 3-year-old filly was discovered clinically and removed and examined after the horse had been humanely killed. Histologically, three different tissue types were noted, occurring in equal amounts: epithelium largely in the form of well-differentiated tubules, multifocally distributed cell-dense foci of blastema, and myxoid to fibrous stroma. A diagnosis of triphasic nephroblastoma, a rare tumour in the horse, was made on the basis of microscopical findings. The finding of numerous glomeruloid structures confirmed the diagnosis and assisted in distinguishing the tumour from a teratoma. The histogenesis of nephroblastoma is briefly discussed in the context of the histological and immunohistochemical findings of the case.
在一匹3岁小母马身上临床发现一个大的腹部肿块，在对该马实施安乐死后将肿块切除并进行检查。组织学检查发现三种不同的组织类型，数量相等：上皮组织主要呈分化良好的小管形式，多灶性分布的细胞密集的胚基灶，以及黏液样至纤维性基质。根据显微镜检查结果，诊断为三相性肾母细胞瘤，这是马身上一种罕见的肿瘤。大量肾小球样结构的发现证实了诊断，并有助于将该肿瘤与畸胎瘤区分开来。结合该病例的组织学和免疫组化结果，简要讨论了肾母细胞瘤的组织发生。
