Yamamoto Yu, Yamada Manabu, Nakamura Kikuyasu, Takahashi Yuji, Miyamoto Toru
National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki, Japan.
J Vet Med Sci. 2006 Aug;68(8):891-3. doi: 10.1292/jvms.68.891.
This paper describes a nephroblastoma with transcoelomic metastasis in a three-year-old Japanese black bull. At necropsy, a huge, oval neoplastic mass containing the residual right kidney was found. Moreover, severe transcoelomic metastasis occurred throughout the abdominal and thoracic cavities. Histologically, the mass was mainly composed of sheets, nests, islands and cords of polygonal blastemal cells with trabeculae of fibrous stroma. In some areas, epithelial elements composed of tubules and winding duct-like structures were also observed. Glomeruloid structures were scattered in these epithelial elements. Metastatic nodules were composed of blastemal and stromal elements, which were similar to those in the mass.
本文描述了一头三岁日本黑牛患有的伴有腹腔内转移的肾母细胞瘤。尸检时，发现一个巨大的椭圆形肿瘤块，其中包含残余的右肾。此外，在整个腹腔和胸腔均发生了严重的腹腔内转移。组织学上，肿瘤块主要由多边形胚基细胞的片状、巢状、岛状和索状结构组成，并伴有纤维性间质小梁。在某些区域，还观察到由小管和蜿蜒的导管样结构组成的上皮成分。类肾小球结构散在于这些上皮成分中。转移结节由胚基和间质成分组成，与肿瘤块中的成分相似。
