Hogquist K A, Bevan M J
Department of Lab Medicine and Pathology, University of Minnesota, Minneapolis 55455, USA.
Semin Immunol. 1996 Apr;8(2):63-8. doi: 10.1006/smim.1996.0009.
Positive and negative selection in the thymus occur when the TCR on an immature thymocyte engages self peptide/MHC complexes present on epithelial cells. The signaling mechanism which dictates the selection outcome is currently a matter of intense investigation. Here we review experiments that defined the peptide ligands for positive selection. A comparison of these to the peptide ligands that induce negative selection (antigenic peptides) sheds some insight into how a thymocyte interprets peptide/MHC interactions leading to life versus death of the cell.
当未成熟胸腺细胞上的TCR与上皮细胞上存在的自身肽/MHC复合物结合时，胸腺中就会发生阳性和阴性选择。决定选择结果的信号传导机制目前是深入研究的课题。在这里，我们回顾了确定阳性选择肽配体的实验。将这些配体与诱导阴性选择的肽配体（抗原肽）进行比较，有助于深入了解胸腺细胞如何解读肽/MHC相互作用，从而决定细胞的生死。
