Ziegler Andreas, Müller Claudia A, Böckmann Rainer A, Uchanska-Ziegler Barbara
Institut für Immungenetik, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Freie Universität Berlin, Thielallee 73, 14195 Berlin, Germany.
Trends Immunol. 2009 Feb;30(2):53-60. doi: 10.1016/j.it.2008.11.004. Epub 2009 Feb 7.
The dual requirement for T cells to recognize a particular major histocompatibility complex (MHC) antigen presenting a foreign peptide and to lack strong reactivity with a complex of the same molecule when bound to a self-peptide, is attained by thymic positive and negative selection processes, the molecular details of which are currently only partially understood. However, the discovery of the thymoproteasome and our improved understanding of the dynamics of peptide presentation permit us to suggest that the biophysical properties of the MHC:peptide class I complexes engaged in positive T-cell selection will be distinct from those involved in negative selection, hence imposing differential barriers for T cells.
T细胞识别呈递外来肽的特定主要组织相容性复合体（MHC）抗原，且与结合自身肽时的同一分子复合物缺乏强反应性，这一双重要求是通过胸腺的阳性和阴性选择过程实现的，目前对其分子细节仅部分了解。然而，胸腺蛋白酶体的发现以及我们对肽呈递动力学的深入理解使我们提出，参与阳性T细胞选择的MHC:肽I类复合物的生物物理特性将与参与阴性选择的复合物不同，因此对T细胞构成不同的屏障。
