Tokino T
Laboratory of Molecular Medicine, University of Tokyo.
Nihon Rinsho. 1996 Apr;54(4):960-4.
Alterations of p53 tumor suppressor gene are the most common genetic change detected in human cancers. Several biological functions of p53 have been described, including the induction of G1 arrest and apoptosis following DNA damage or other cellular insults. Biochemical activity of p53 has been proposed as a transcriptional regulator; p53 gene product can bind DNA in a sequence-specific manner and regulate transcription from promoters containing a consensus binding site. It is likely that many of the biological functions of p53 are a result of transcriptional regulation of downstream genes which involve in these functions.
p53肿瘤抑制基因的改变是在人类癌症中检测到的最常见的基因变化。p53的几种生物学功能已被描述，包括DNA损伤或其他细胞损伤后诱导G1期阻滞和凋亡。p53的生化活性被认为是一种转录调节因子；p53基因产物能以序列特异性方式结合DNA，并调节来自含有共有结合位点的启动子的转录。p53的许多生物学功能可能是涉及这些功能的下游基因转录调控的结果。
