Ito M, Ohtsuru A
Department of Pathology, Nagasaki University, School of Medicine.
Nihon Rinsho. 1996 Apr;54(4):1104-8.
Parathyroid hormone-related peptide (PTHrP), originally isolated as a responsible factor for humoral hypercalcemia of malignancy, has been demonstrated to overexpress even in non-hypercalcemic gastrointestinal malignancies. PTHrP and its receptor mRNA expression has been detected in a variety of normal tissues in neonate and adults. PTHrP might be involved in growth and differentiation on fetal gut epithelium, and an important gastrointestinal peptide which regulates gastrointestinal contractile activity in a paracrine/autocrine fashion. Exogenous PTHrP shows a relaxant effect on gastrointestinal muscle strips through PTH/PTHrP receptor in vitro. Increase PTHrP mRNA was induced by distention and contraction in the smooth muscle of the stomach, and stress-induced abnormal contractions was deeply related to PTHrP suppression by steroid.
甲状旁腺激素相关肽（PTHrP）最初作为恶性肿瘤体液性高钙血症的致病因素被分离出来，现已证明即使在非高钙血症的胃肠道恶性肿瘤中也会过度表达。在新生儿和成人的多种正常组织中都检测到了PTHrP及其受体mRNA的表达。PTHrP可能参与胎儿肠道上皮的生长和分化，是一种以旁分泌/自分泌方式调节胃肠道收缩活动的重要胃肠肽。外源性PTHrP在体外通过PTH/PTHrP受体对胃肠道肌条具有舒张作用。胃平滑肌的扩张和收缩可诱导PTHrP mRNA增加，应激诱导的异常收缩与类固醇对PTHrP的抑制密切相关。
