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[肾上腺素对恒温动物心肌不同部位收缩性的影响]

[Effect of adrenaline on the contractility of different portions of the myocardium of homeotherms].

作者信息

Shumakov V I, Shtengol'd E G, Itkin G P, Egorov T L, Protsenko Iu L

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1977 May;63(5):697-706.

PMID:892078
Abstract

The contractility of myocardial strips from the atrium and ventricle of rabbit heart had some differences in the parameters of single contraction, interval--tension relationship, and transitional process. These differences were eliminated by increasing the concentration of epinephrine in bath solution. Epinephrine changed the mode of time--force relation of contraction and induced appearance of extremum in all the parts of the heart. The linear relation between the force of atrium contraction and that of ventricle contraction (homochromity) during change of contraction frequency in normal solution, was shown. The homochromity of atrium and ventricle was broken by high epinphrine concentrations. The level of endogenous catecholamines which modulate the excitation--contraction relations, is believed to determine the differences in the physiological reactions of atrial and ventricular strips. The use of atrium of the heart as a transducer for management of artificial heart is proposed.

摘要

兔心脏心房和心室肌条的收缩性在单收缩参数、间期-张力关系及过渡过程方面存在一些差异。通过增加浴液中肾上腺素的浓度可消除这些差异。肾上腺素改变了收缩的时间-力关系模式,并在心脏各部位诱发了极值的出现。结果显示,在正常溶液中收缩频率改变时,心房收缩力与心室收缩力之间存在线性关系(同色性)。高浓度肾上腺素会破坏心房和心室的同色性。据信,调节兴奋-收缩关系的内源性儿茶酚胺水平决定了心房和心室肌条生理反应的差异。提出将心脏心房用作人工心脏管理的换能器。

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