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[低温状态下的心脏能量学]

[Cardiac energetics in hypothermia].

作者信息

Aliukhin Iu S

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1977 Jul;63(7):1011-5.

PMID:892085
Abstract

In isolated hearts of rats pumping a fluid against hydrostatic pressure, the effect of cooling to 27 degrees C on the mechanical efficiency (ME) and oxygen consumption (MVO2) of the heart, was studied. The ME was presented by the ratio of the heart work to the total energy expense. The latter was estimated by MVO2 measured by the polarographic method. At 27 degrees C, the ME was increased while the MVO2 of the arrested heart was decreased. MVO2 of the working heart in hypothermia was less than control by the same valve as the MVO2 of the heart arrested in hypothermia was less than MVO2 of the arrested control heart. The increase of the heart ME in hypothermia seems to be due, mainly, to reduced "rest metabolism" of the heart.

摘要

在给大鼠离体心脏灌注液体以对抗流体静压的实验中,研究了将心脏冷却至27摄氏度对心脏机械效率(ME)和耗氧量(MVO2)的影响。ME通过心脏做功与总能量消耗的比值来表示。后者通过极谱法测量的MVO2进行估算。在27摄氏度时,停跳心脏的MVO2降低,而ME增加。低温下工作心脏的MVO2比对照组降低的幅度,与低温下停跳心脏的MVO2比停跳对照心脏的MVO2降低的幅度相同。低温下心脏ME的增加似乎主要是由于心脏“静息代谢”的降低。

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