Das S K, Ray P K
Department of Biochemistry and Biophysics, University of Kalyani, India.
Biochem Biophys Res Commun. 1996 Nov 12;228(2):544-8. doi: 10.1006/bbrc.1996.1696.
The developmental profiles of gamma-aminobutyric acid (GABA), its biosynthesizing enzyme L-glutamic acid decarboxylase (GAD) and its degradating enzymes gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH) in four different regions of human fetal brains have been evaluated. The GABA pathway was found to be maximally active in fetal brains during the third trimester of pregnancy. The relative activities of the enzymes as well as GABA content were least in pons compared to cerebrum, cerebellum and mid brain regions throughout the period of fetal development.
已对人胎儿大脑四个不同区域中γ-氨基丁酸（GABA）、其生物合成酶L-谷氨酸脱羧酶（GAD）及其降解酶γ-氨基丁酸-α-酮戊二酸转氨酶（GABA-T）和琥珀酸半醛脱氢酶（SSADH）的发育情况进行了评估。发现GABA途径在妊娠晚期胎儿大脑中活性最高。在整个胎儿发育期间，与大脑、小脑和中脑区域相比，脑桥中这些酶的相对活性以及GABA含量最低。
