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γ-氨基丁酸代谢的三种酶在猴视网膜中的分布

Distribution of three enzymes of gamma-aminobutyric acid metabolism in monkey retina.

作者信息

Pusateri M E, Carter J G, Berger S J, Lowry O H

出版信息

J Neurochem. 1984 May;42(5):1269-72. doi: 10.1111/j.1471-4159.1984.tb02782.x.

DOI:10.1111/j.1471-4159.1984.tb02782.x
PMID:6707630
Abstract

The distributions of glutamate decarboxylase (EC 4.1.1.15), gamma-aminobutyric acid transaminase (EC 2.6.1.19), and succinate semialdehyde dehydrogenase (EC 1.2.1.24) were determined in monkey retina. The decarboxylase was almost restricted to the inner plexiform layer. The transaminase was also highest in this layer, but activities were 40% as high in the adjacent third of the inner nuclear layer and in the ganglion cell and fiber layers. Succinate semialdehyde dehydrogenase was distributed very differently. Although it also showed a peak of activity in the inner plexiform layer, there was a second equal peak in the photoreceptor inner segment layer and a smaller peak in the outer plexiform layer, regions where both gamma-aminobutyric acid transaminase and glutamate decarboxylase were essentially absent.

摘要

在猴视网膜中测定了谷氨酸脱羧酶(EC 4.1.1.15)、γ-氨基丁酸转氨酶(EC 2.6.1.19)和琥珀酸半醛脱氢酶(EC 1.2.1.24)的分布。脱羧酶几乎局限于内网状层。转氨酶在该层中也最高,但在内核层相邻的三分之一区域以及神经节细胞层和纤维层中的活性为其40%。琥珀酸半醛脱氢酶的分布则大不相同。虽然它在内网状层也显示出活性峰值,但在光感受器内节层有第二个同等的峰值,在外网状层有一个较小的峰值,而γ-氨基丁酸转氨酶和谷氨酸脱羧酶在这些区域基本不存在。

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引用本文的文献

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Antioxid Redox Signal. 2011 Aug 1;15(3):691-718. doi: 10.1089/ars.2010.3470. Epub 2011 Apr 10.
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Aspartate aminotransferase and glutaminase activities in rat olfactory bulb and cochlear nucleus; comparisons with retina and with concentrations of substrate and product amino acids.
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Neurochem Res. 1994 Jun;19(6):693-703. doi: 10.1007/BF00967708.
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