Shabunova I A
Fiziol Zh SSSR Im I M Sechenova. 1977 Jul;63(7):964-9.
The influence of L-histidine in different concentrations (0.2--9.0mM) on synaptic processes in neuro-muscular preparations of the frog was studied using intracellular microelectrodes. The histidine caused lowering of the frequency of m. e. p. p. In the synapses with initial quantum content of e. p. p. less than 50, the increase of quantum content occurred due to rising of the available mediator level. The possibility of the transmitter release did not change. The histidine seems to participate in positive functional feedback in a neuro-muscular synapse, the feedback maybe essential for mobilization of the inactive synapses during intense muscular activity.
利用细胞内微电极研究了不同浓度(0.2 - 9.0mM)的L-组氨酸对青蛙神经肌肉制剂突触过程的影响。组氨酸导致微小终板电位(m.e.p.p.)频率降低。在终板电位(e.p.p.)初始量子含量小于50的突触中,量子含量的增加是由于可用递质水平的升高。递质释放的可能性没有改变。组氨酸似乎参与了神经肌肉突触中的正性功能反馈,这种反馈可能对剧烈肌肉活动期间无活性突触的动员至关重要。