用病毒特异性抗血清抑制释放内源性C型病毒的大鼠胚胎细胞的自发转化。
Inhibition of spontaneous transformation of rat embryo cells releasing endogenous type C virus by virus-specific antiserum.
作者信息
Rasheed S, Young H, Gardner M B
出版信息
J Natl Cancer Inst. 1979 Sep;63(3):745-50. doi: 10.1093/jnci/63.3.745.
PMID:89211
Abstract
Noninbred Sprague-Dawley rat embryo cell clones predictably undergo transformation after 20-30 in vitro passages following spontaneous release of endogenous rat leukemia virus (RaLV). In the presence of RaLV-specific antiserum, virus production and infectivity were reduced and transformation was delayed from 6 to 25 weeks. Transformation was not associated with an increased expression of Kirsten murine sarcoma virus-related src gene RNA.
摘要
非近交系斯普拉格-道利大鼠胚胎细胞克隆在自发性释放内源性大鼠白血病病毒（RaLV）后，经过20 - 30次体外传代后可预测地发生转化。在存在RaLV特异性抗血清的情况下，病毒产生和感染性降低，转化从6周延迟至25周。转化与柯斯顿鼠肉瘤病毒相关src基因RNA的表达增加无关。
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