Wu T N, Shen C Y, Ko K N, Guu C F, Gau H J, Lai J S, Chen C J, Chang P Y
Department of Health, Executive Yuan, Taipei, Taiwan, ROC.
Int J Epidemiol. 1996 Aug;25(4):791-6. doi: 10.1093/ije/25.4.791.
To assess the relation between occupational lead exposure and elevated blood pressure with consideration of a possible confounding effect by noise exposure.
Some 112 male and 110 female workers at two lead battery manufacturing factories were recruited for this 1992 study in Taiwan. Study participants received regular physical examinations, including standard measurement of blood pressure, body height/weight. Current occupational exposures to lead and noise were measured by a personal sampling scheme and instruments, and included individual ambient lead/noise exposure and blood lead level.
Among the 222 battery-factory workers, the average blood lead level was 56.9 +/- 25.5 micrograms/dl (mean +/- standard deviation), the average concentration of ambient lead exposure was 0.190 +/- 0.331 mg/m3, average noise exposure was 85.9 +/- 5.7 dBA, average systolic blood pressure was 125.2 +/- 14.9 mmHg, average diastolic pressure was 80.2 +/- 10.9 mmHg, and average mean arterial pressure was 95.2 +/- 11.1 mmHg. After considering all possible confounding variables, multivariate regression analyses demonstrated that current blood lead level was not a significant predictor for both systolic and diastolic blood pressures in either sex. In the final model, body mass index and years of working in the factory were the only two factors significantly associated with a change in blood pressure. No evidence of an effect of ambient lead exposure or noise exposure on blood pressure were found.
The present study suggests that short-term lead exposure, either ambient lead exposure or blood lead level, was not related to blood pressure change among workers who had been exposed at work to occupational lead. These results add to the body of evidence indicating that blood lead exposure does not adversely affect blood pressure.
考虑到噪声暴露可能产生的混杂效应，评估职业性铅暴露与血压升高之间的关系。
1992年在台湾，招募了两家铅酸蓄电池制造工厂的约112名男性和110名女性工人参与本研究。研究参与者接受了定期体检，包括标准血压测量、身高/体重测量。通过个人采样方案和仪器测量当前职业性铅和噪声暴露情况，包括个体环境铅/噪声暴露和血铅水平。
在222名蓄电池厂工人中，平均血铅水平为56.9±25.5微克/分升（均值±标准差），环境铅暴露平均浓度为0.190±0.331毫克/立方米，平均噪声暴露为85.9±5.7分贝A，平均收缩压为125.2±14.9毫米汞柱，平均舒张压为80.2±10.9毫米汞柱，平均平均动脉压为95.2±11.1毫米汞柱。在考虑所有可能的混杂变量后，多因素回归分析表明，当前血铅水平在男性和女性中均不是收缩压和舒张压的显著预测因素。在最终模型中，体重指数和在工厂工作的年限是与血压变化显著相关的仅有的两个因素。未发现环境铅暴露或噪声暴露对血压有影响的证据。
本研究表明，对于工作中接触职业性铅的工人，短期铅暴露，无论是环境铅暴露还是血铅水平，均与血压变化无关。这些结果进一步证明血铅暴露不会对血压产生不利影响。
