Yuasa T
Department of Obstetrics and Gynecology, Okayama University Medical School.
Nihon Sanka Fujinka Gakkai Zasshi. 1996 Oct;48(10):867-74.
To clarify the pattern of cytokeratin and vimentin expression in mixed adenocarcinoma and squamous cell carcinoma of the uterine cervix, twenty-three cases of formalin-fixed paraffin-embedded specimen were examined immunohistochemically using a panel of four different monoclonal anti-cytokeratin antibodies and anti-vimentin antibody. Fifty-seven cases of benign or malignant tissue were selected for controls. The results were summarized as follows. 1) In four cases of co-existing adenocarcinoma and squamous cell carcinoma, their immunostaining patterns were compatible with original histological cell type. 2) In four cases of adenoacanthoma, high molecular weight-cytokeratin (HCK) was positive in each acanthomatous component and only a small part of one adenocarcinomatous component. 3) In twelve cases of cervical adenosquamous carcinoma, HCK were positive in four adenocarcinomatous components. Out of eight cases with non-stained adenocarcinomatous components, six cases showed negativity for HCK even in the squamous cell carcinomatous component. 4) Though vimentin was negative in all cases of mixed type of cervical carcinoma, some cases of mixed type endometrial carcinoma were stained positively for vimentin. It was indicated from our study that adenosquamous carcinoma of the cervix could originate either in reserve cells or columunar epithelium and that vimentin positive cases could originate in the endometorial gland.
为明确子宫颈混合性腺癌和鳞状细胞癌中细胞角蛋白和波形蛋白的表达模式，我们使用一组四种不同的抗细胞角蛋白单克隆抗体和抗波形蛋白抗体，对23例福尔马林固定石蜡包埋标本进行了免疫组织化学检查。选择57例良性或恶性组织作为对照。结果总结如下：1）在4例同时存在腺癌和鳞状细胞癌的病例中，其免疫染色模式与原始组织学细胞类型相符。2）在4例腺棘皮癌中，高分子量细胞角蛋白（HCK）在每个棘皮瘤成分中呈阳性，仅在一个腺癌成分的一小部分中呈阳性。3）在12例宫颈腺鳞癌中，HCK在4个腺癌成分中呈阳性。在8例腺癌成分未染色的病例中，6例即使在鳞状细胞癌成分中HCK也呈阴性。4）虽然波形蛋白在所有宫颈混合性癌病例中均为阴性，但一些子宫内膜混合性癌病例波形蛋白呈阳性染色。我们的研究表明，宫颈腺鳞癌可能起源于储备细胞或柱状上皮，波形蛋白阳性病例可能起源于子宫内膜腺。
