Liu C Y, Kuo H P
Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
Changgeng Yi Xue Za Zhi. 1996 Sep;19(3):211-6.
We examined the effects of salbutamol, aminophylline and verapamil on plasma exudation into airway wall and lumen in guinea pig trachea isolated in situ. Platelet-activating factor (PAF) (50 ng/kg) induced plasma exudation into both the tissue and lumen. Aminophylline (25 mg/kg) eliminated PAF-induced plasma leakage in the tissue and lumen. Verapamil (500 micrograms/kg) had neither effect. Salbutamol (160 micrograms/kg) significantly reduced PAF-induced plasma exudation in the tissue and enhanced plasma recovery in the airway lumen. We conclude that aminophylline inhibited microvascular leakage whereas salbutamol facilitates exudated plasma across epithelium and reduced its accumulation in the tissue.
我们研究了沙丁胺醇、氨茶碱和维拉帕米对原位分离的豚鼠气管中血浆渗出到气道壁和管腔的影响。血小板活化因子（PAF）（50 ng/kg）可诱导血浆渗出到组织和管腔中。氨茶碱（25 mg/kg）可消除PAF诱导的组织和管腔中的血浆渗漏。维拉帕米（500微克/千克）无此作用。沙丁胺醇（160微克/千克）可显著减少PAF诱导的组织中的血浆渗出，并促进气道管腔中的血浆回收。我们得出结论，氨茶碱可抑制微血管渗漏，而沙丁胺醇则促进渗出的血浆穿过上皮细胞，并减少其在组织中的积聚。
