Onishi Y, Yonekura Y, Tanaka F, Nishizawa S, Okazawa H, Ishizu K, Fujita T, Konishi J, Mukai T
Nihon Medi-Physics Co. Ltd.
Kaku Igaku. 1996 Sep;33(9):953-63.
Parametric images of intrasubject distribution of the central-type benzodiazepine receptor binding and ligand transport were determined from two SPECT images after an intravenous bolus injection of 123I-iomazenil in six healthy volunteers and five patients by using a table look-up procedure based on a 3-compartment, 2-parameter kinetic model. Individual arterial input functions were estimated by calibrating a standardized input function with the injected dose to avoid blood sampling. The parametric images without blood data provided the same information as those determined by using measured arterial input function. A simulation study suggested that this method gave relatively small error as long as true receptor binding and ligand transport did not differ from each other in a large extent. The present method may be practical in clinical settings.
通过基于三室、双参数动力学模型的查表程序，在6名健康志愿者和5名患者静脉推注123I-碘美仑后，从两张单光子发射计算机断层扫描（SPECT）图像中确定了中枢型苯二氮䓬受体结合和配体转运的体内分布参数图像。通过将标准化输入函数与注射剂量进行校准来估计个体动脉输入函数，以避免采血。无血液数据的参数图像提供了与使用实测动脉输入函数确定的图像相同的信息。一项模拟研究表明，只要真正的受体结合和配体转运在很大程度上没有差异，该方法产生的误差相对较小。本方法在临床环境中可能具有实用性。
