Matsumura K, Watanabe Y, Aoki S, Nakashima H, Maeda H, Hirano T, Takeda K, Nakagawa T
Department of Radiology, Mie University School of Medicine.
Kaku Igaku. 1996 Sep;33(9):1021-6.
We evaluated regional cerebral blood flow in the hippocampus in 21 patients with neurological disorders by 99mTc-ethyl cysteinate dimer (ECD) SPECT and compared the findings with those by 123I-N-isopropyl-p-iodoamphetamine (IMP) SPECT. In all subjects, SPECT was taken using ECD (740 MBq) and IMP (167 MBq) using high performance SPECT (3-head SPECT, Toshiba GCA-9300A/HG) within 3 weeks interval. Regional uptake in the hippocampus was examined in the coronal sections and images parallel to the longitudinal axis of hippocampus. ECD and IMP showed similar hippocampal uptake in 9 cases, but ECD showed less uptake than IMP in 12 cases (57%). Regional counts in the hippocampus were related to the counts in the lateral temporal cortices and the mean count ratio was lower in ECD by 8.8% than that in IMP (0.73 +/- 0.11 vs. 0.80 +/- 0.11, p < 0.001). In 6 patients suspected to have hippocampal lesion (4 cases of memory disturbance and 2 cases of epilepsy), all cases showed decreased uptake of ECD in hippocampus, but only 3 cases showed decreased uptake of IMP. This is suggestive to be relevant to the difference in the retention mechanism of ECD and IMP, but further investigation should be performed.
我们采用99mTc-半胱氨酸乙酯二聚体（ECD）单光子发射计算机断层扫描（SPECT）对21例神经系统疾病患者海马区的局部脑血流进行了评估，并将结果与123I-N-异丙基-p-碘安非他明（IMP）SPECT的结果进行了比较。在所有受试者中，间隔3周内使用高性能SPECT（3探头SPECT，东芝GCA-9300A/HG）分别用ECD（740MBq）和IMP（167MBq）进行SPECT检查。在冠状面以及与海马纵轴平行的层面上观察海马区的摄取情况。ECD和IMP在9例患者中显示出海马摄取相似，但在12例患者（57%）中，ECD的摄取低于IMP。海马区的局部计数与颞叶外侧皮质的计数相关，ECD的平均计数率比IMP低8.8%（0.73±0.11对0.80±0.11，p<0.001）。在6例疑似海马病变的患者中（4例记忆障碍和2例癫痫），所有病例均显示海马区ECD摄取减少，但只有3例显示IMP摄取减少。这提示可能与ECD和IMP的滞留机制差异有关，但还需进一步研究。
