Ishizuka H, Tomi H, Sunohara N
Department of Neurology, Murayama National Hospital.
Nihon Ronen Igakkai Zasshi. 1996 Aug;33(8):586-91. doi: 10.3143/geriatrics.33.586.
Movement-related cortical potentials (MRCP) were measured in young normal subjects (age < 40) and aged normal subjects (age > or = 60). All were right-handed. MRCPs were recorded for voluntary self-paced extension of the right middle finger or the right foot. For the middle finger extension the latency and slope of the Bereitschaftspotential (BP) and the negative slope (NS') were measured at the contralateral hand motor area, and for the foot movement they were measured from Cz. MRCPs for the finger extension were examined in 12 young subjects (5 men, 7 women, 22-38 years old, mean age 26.3 +/- 5.2 years) and 18 aged subjects (9 men, 9 women, 60-82 years old, mean age 69.4 +/- 7.2 years). BP latency and NS' latency were significantly longer in the aged subjects than in the young subjects (p < 0.001 and p < 0.05, respectively). MRCPs for the foot movement were measured in 10 young subjects (3 men, 7 women, 22-38 years old, mean age 27.1 +/- 5.4 years) and 10 aged subjects (5 men, 5 women, 60-82 years old, mean age 70.3 +/- 8.1 years). BP latency was significantly longer in the aged subjects than in the young subjects (p < 0.05), but NS' latency was not. For both finger and foot extension, neither BP slope nor NS' slope differed significantly between the groups, although both slopes were steeper in the young subjects than the aged ones. These findings suggest that the time required by the cerebrum to prepare for voluntary movement and the period of preparation for movement are longer in aged subjects than in young subjects.
在年轻正常受试者（年龄<40岁）和老年正常受试者（年龄≥60岁）中测量了与运动相关的皮层电位（MRCP）。所有受试者均为右利手。记录了右手中指或右脚自主自定节奏伸展时的MRCP。对于中指伸展，在对侧手部运动区测量准备电位（BP）的潜伏期和斜率以及负斜率（NS'），对于足部运动，则从Cz点进行测量。对12名年轻受试者（5名男性，7名女性，年龄22 - 38岁，平均年龄26.3±5.2岁）和18名老年受试者（9名男性，9名女性，年龄60 - 82岁，平均年龄69.4±7.2岁）进行了手指伸展的MRCP检查。老年受试者的BP潜伏期和NS'潜伏期显著长于年轻受试者（分别为p<0.001和p<0.05）。对10名年轻受试者（3名男性，7名女性，年龄22 - 38岁，平均年龄27.1±5.4岁）和10名老年受试者（5名男性，5名女性，年龄60 - 82岁，平均年龄70.3±8.1岁）进行了足部运动的MRCP测量。老年受试者的BP潜伏期显著长于年轻受试者（p<0.05），但NS'潜伏期无显著差异。对于手指和足部伸展，两组之间的BP斜率和NS'斜率均无显著差异，尽管年轻受试者的两个斜率均比老年受试者更陡。这些发现表明，与年轻受试者相比，老年受试者大脑为自主运动做准备所需的时间以及运动准备期更长。
