Oguri T, Onda M, Tokunaga A, Asano G
First Department of Surgery, Nippon Medical School.
Nihon Shokakibyo Gakkai Zasshi. 1996 Oct;93(10):707-16.
Expression of trefoil group antigen pS2 was examined immunohistochemically in resected stomachs from 121 patients with gastric cancer. Gastric cancer was classified as either undifferentiated or differentiated by histology, and was also divided into gastric type or non-gastric type by mucin-histochemistry. Immunoreactive pS2 was present in 20% of early cancers and 30% of advanced cancers (NS), and in 25% of undifferentiated and 15% of differentiated early cancers (NS), whereas the antigen was present in 38% of undifferentiated and 15% of differentiated advanced cancers (p = 0.04). Positivity for pS2 was found more often in gastric type early cancer (p = 0.04) as well as advanced cancer (p = 0.0002), and was also more frequent in cancers showing scirrhous (p = 0.04) and infiltrative growth (p = 0.03). Cancer positive for pS2 was characterized by mucin-histochemistry and microscopy as gastric type with scirrhous growth and diffuse infiltration, and thus the expression of pS2 in gastric cancer appears to be related to the growth of cancer with these characteristics.
采用免疫组织化学方法检测了121例胃癌患者手术切除胃组织中三叶因子组抗原pS2的表达情况。胃癌根据组织学分为未分化型或分化型，同时根据黏液组织化学分为胃型或非胃型。免疫反应性pS2在20%的早期癌症和30%的进展期癌症中存在（无统计学差异），在25%的未分化早期癌症和15%的分化早期癌症中存在（无统计学差异），而该抗原在38%的未分化进展期癌症和15%的分化进展期癌症中存在（p = 0.04）。pS2阳性在胃型早期癌症（p = 0.04）以及进展期癌症（p = 0.0002）中更常见，在表现为硬癌（p = 0.04）和浸润性生长（p = 0.03）的癌症中也更频繁。pS2阳性的癌症在黏液组织化学和显微镜下的特征为胃型，伴有硬癌生长和弥漫性浸润，因此pS2在胃癌中的表达似乎与具有这些特征的癌症生长有关。
