Wu M S, Shun C T, Wang H P, Lee W J, Wang T H, Lin J T
Department of Internal Medicine, National Taiwan University Hospital, Taipei.
Jpn J Cancer Res. 1998 Mar;89(3):278-82. doi: 10.1111/j.1349-7006.1998.tb00559.x.
To investigate the prevalence of pS2 expression in gastric cancer with respect to tumor histopathology, intestinal metaplasia and Helicobacter pylori (H. pylori) infection, pathologic specimens of 91 patients with gastric cancer were immunostained for pS2. Such immunoreactivity was correlated with the status of H. pylori infection, tumor staging, histology, subtyping, and associated intestinal metaplasia. Positive pS2 staining was seen throughout all non-neoplastic epithelia, and in all 9 patients with the complete type of intestinal metaplasia. In contrast, 21 of 45 incomplete type of intestinal metaplasia had negative pS2 staining (P < 0.001), and 54 out of 91 tumors (59.3%) showed loss of pS2 expression in the cancer tissues proper. There was no correlation of pS2 expression with age, gender, depth of invasion, duodenal involvement, lymph node metastasis, venous invasion or H. pylori infection. Negative pS2 staining was significantly higher in the intestinal (74.5%) and Borrmann type I, II, III (64.2%) tumors than the diffuse (43.2%, P < 0.005) and Borrmann type IV (20%, P < 0.05) tumors. Our results indicate that loss of pS2 expression may occur as an early event in the malignant transformation process of intestinal-type tumors.
为了研究pS2在胃癌中的表达情况与肿瘤组织病理学、肠化生及幽门螺杆菌（H. pylori）感染之间的关系，对91例胃癌患者的病理标本进行了pS2免疫染色。这种免疫反应性与H. pylori感染状况、肿瘤分期、组织学、亚型及相关肠化生有关。在所有非肿瘤上皮以及所有9例完全型肠化生患者中均可见pS2阳性染色。相比之下，45例不完全型肠化生患者中有21例pS2染色阴性（P < 0.001），91例肿瘤中有54例（59.3%）在癌组织中出现pS2表达缺失。pS2表达与年龄、性别、浸润深度、十二指肠受累情况、淋巴结转移、静脉侵犯或H. pylori感染无关。肠型肿瘤（74.5%）以及Borrmann I型、II型、III型肿瘤（64.2%）中pS2染色阴性显著高于弥漫型肿瘤（43.2%，P < 0.005）和Borrmann IV型肿瘤（20%，P < 0.05）。我们的结果表明，pS2表达缺失可能是肠型肿瘤恶性转化过程中的早期事件。
