Redington A N, Somerville J
Department of Pediatric Cardiology, Royal Brompton Hospital, London, England.
Circulation. 1996 Nov 15;94(10):2479-84. doi: 10.1161/01.cir.94.10.2479.
The optimal treatment of patients with complex pulmonary atresia remains controversial. Surgical unifocalization programs are increasing popular but have not previously or currently gained universal acceptance. Furthermore, not all patients are suitable for attempts at biventricular correction. These patients may become increasingly symptomatic and require palliation.
We attempted to palliate 12 patients with progressive symptomatic hypoxemia. Each had at least one stenotic but balloon-dilatable collateral supplying at least three lung segments. It was impossible to traverse the stenotic area with the stent in 1 patient, despite two attempts. Twelve stents were thus deployed in 11 patients. There was no effect in 1 patient who had multiple stenoses distal to the stented area. There was excellent palliation in the remainder, arterial oxygen saturation 45% to 79% before stenting (mean, 64 +/- 12%) rising to 67% to 90% (mean, 78 +/- 10%, P < .01) at discharge from hospital. One patient was referred for surgery to secure blood flow to a nearly totally occluded side branch to the right upper lobe traversed by the stent. There was an excellent symptomatic response in the remainder, with an early increase in exercise duration (P < .01). Late arterial desaturation occurred in 2 patients. In 1, there was pulmonary arterial hypertension in the lung segments supplied by the stented vessel. A stenosis had developed within the stent in the other patient, who was noncompliant with anticoagulation therapy.
Stenting of stenotic aortopulmonary collaterals can achieve excellent palliation in the majority of this highly selected subgroup of patients with complex pulmonary atresia.
复杂型肺动脉闭锁患者的最佳治疗方案仍存在争议。手术单灶化方案越来越普遍,但此前或目前尚未得到普遍认可。此外,并非所有患者都适合尝试双心室矫正。这些患者可能症状日益加重,需要进行姑息治疗。
我们试图对12例有进行性症状性低氧血症的患者进行姑息治疗。每例患者至少有一条狭窄但可通过球囊扩张的侧支血管,为至少三个肺段供血。尽管尝试了两次,但有1例患者的支架无法穿过狭窄区域。因此,在11例患者中植入了12枚支架。有1例患者在支架置入区域远端存在多处狭窄,治疗无效。其余患者的姑息治疗效果良好,支架置入前动脉血氧饱和度为45%至79%(平均为64±12%),出院时升至67%至90%(平均为78±10%,P<.01)。有1例患者被转诊接受手术,以确保血流至由支架穿过的右上叶几乎完全闭塞的侧支。其余患者的症状反应良好,运动持续时间早期增加(P<.01)。2例患者出现晚期动脉血氧饱和度降低。1例患者在由支架置入血管供血的肺段出现肺动脉高压。另1例患者的支架内出现狭窄,该患者未遵医嘱进行抗凝治疗。
对于大多数经过严格筛选的复杂型肺动脉闭锁患者亚组,对狭窄的主肺动脉侧支进行支架置入可实现良好的姑息治疗效果。