Bartfield J M, Lee F S, Raccio-Robak N, Salluzzo R F, Asher S L
Department of Emergency Medicine, Albany Medical College, NY 12208, USA.
Acad Emerg Med. 1996 Nov;3(11):1001-5. doi: 10.1111/j.1553-2712.1996.tb03341.x.
To determine whether topical tetracaine attenuates the pain of buffered lidocaine infiltration.
A prospective, randomized, double-blind trial was conducted involving adults with lacerations being repaired following local anesthesia. Two 0.5-mL injections of buffered lidocaine were given in a standardized manner. Injection 1 was given prior to application of topical study solution. Injection 2 was given on the opposite side of the laceration after topical application of a study solution that was 4 mL of either tetracaine or normal saline. Pain of each infiltration was measured using a visual analog pain scale. Pain score differences (injection 1 - injection 2) were compared for the 2 study solutions using a Wilcoxon 2-sample signed-rank test.
Of 57 subjects studied, 29 received tetracaine and 28 received saline. The groups were similar in age, gender, wound length, wound location, and initial pain score. Pain scores decreased significantly in the tetracaine group as compared with the saline group. The median pain score difference for tetracaine was 12.0 mm, with an interquartile range (IQR) of 2 to 43 mm, as compared with 2 mm, with an IQR of - 17 to 21 mm for saline (p = 0.048).
Topical tetracaine attenuates the pain of infiltration of buffered lidocaine.
确定局部应用丁卡因是否能减轻缓冲利多卡因浸润引起的疼痛。
进行了一项前瞻性、随机、双盲试验，纳入接受局部麻醉后进行伤口缝合的成人。以标准化方式给予两次0.5毫升缓冲利多卡因注射。注射1在局部应用研究溶液之前进行。注射2在伤口的另一侧进行，在局部应用4毫升丁卡因或生理盐水的研究溶液之后。使用视觉模拟疼痛量表测量每次浸润的疼痛程度。使用Wilcoxon双样本符号秩检验比较两种研究溶液的疼痛评分差异（注射1 - 注射2）。
在57名研究对象中，29人接受丁卡因，28人接受生理盐水。两组在年龄、性别、伤口长度、伤口位置和初始疼痛评分方面相似。与生理盐水组相比，丁卡因组的疼痛评分显著降低。丁卡因的中位疼痛评分差异为12.0毫米，四分位间距（IQR）为2至43毫米，而生理盐水组为2毫米，IQR为 - 17至21毫米（p = 0.048）。
局部应用丁卡因可减轻缓冲利多卡因浸润引起的疼痛。
