Bacci G, Picci P, Ferrari S, Mercuri M, Briccoli A, Donati D, Manfrini M, Zanoni A, Forni C, Campanacci M
Sezione di Chemioterapia, Istituti Ortopedici Rizzoli, Bologna, Italy.
Ann Oncol. 1996 Oct;7(8):864-6. doi: 10.1093/oxfordjournals.annonc.a010769.
Multifocal osteosarcoma is a rare type of tumor which is always excluded from therapy trials and is therefore rarely investigated for prognosis and treatment.
Twelve patients with synchronous multifocal osteosarcoma underwent neoadjuvant chemotherapy and, when feasible, simultaneous resection of involved bones.
Four patients were unsuitable for resection and died 5-13 months (average 9 months) later. In eight patients all lesions were resected simultaneously. Four patients are disease-free at 15, 20, 24, and 60 months (average 29 months), and four relapsed and died at 12, 24, 30 and 36 months (average 30.5 months).
Chemotherapy associated with aggressive surgery may be useful. The histological response of different lesions in the same patient are strongly correlated, confirming that synchronous multifocal osteosarcoma is not originally multicentric but unicentric with bone metastases.
多灶性骨肉瘤是一种罕见的肿瘤类型，在治疗试验中常被排除在外，因此很少对其进行预后和治疗方面的研究。
12例同步性多灶性骨肉瘤患者接受了新辅助化疗，并在可行的情况下对受累骨骼进行了同期切除。
4例患者不适合手术切除，5 - 13个月（平均9个月）后死亡。8例患者所有病灶均同期切除。4例患者在15、20、24和60个月（平均29个月）时无病生存，4例患者分别在12、24、30和36个月（平均30.5个月）复发死亡。
化疗联合积极的手术可能有效。同一患者不同病灶的组织学反应密切相关，证实同步性多灶性骨肉瘤并非原发多中心，而是单中心伴骨转移。
