Ross S A, Cunningham R T, Johnston C F, Rowlands B J
Department of Surgery, Queen's University of Belfast, Northern Ireland.
Br J Neurosurg. 1996 Oct;10(5):471-6. doi: 10.1080/02688699647104.
A statistically significant elevation was observed in serum and CSF neuron-specific enolase (NSE) levels in patients with major head injury, relative to control individuals. No correlation was noted between serum NSE and either APACHE II, Injury Severity Score (ISS), Glasgow Outcome Score (GOS) or Glasgow Coma Scale (GCS). A significant correlation was noted between CSF NSE levels and GCS, but not between CSF NSE and APACHE II, ISS or GOS. Of the patients with major head injury, 100% had NSE CSF levels above the normal level, while 47% had elevated serum NSE levels. In nine patients with major head injury, changes in CSF levels reflected changes in serum NSE levels. In all nine patients, serum NSE decreased to reach normal values, regardless of the outcome as predicted by the GOS. Therefore, while NSE would appear to be a marker of neuronal cell damage, other markers are also essential.
与对照组相比，重度颅脑损伤患者血清和脑脊液中神经元特异性烯醇化酶（NSE）水平有统计学意义的升高。血清NSE与急性生理与慢性健康状况评分系统II（APACHE II）、损伤严重程度评分（ISS）、格拉斯哥预后评分（GOS）或格拉斯哥昏迷量表（GCS）之间均无相关性。脑脊液NSE水平与GCS之间存在显著相关性，但脑脊液NSE与APACHE II、ISS或GOS之间无相关性。重度颅脑损伤患者中，100%的患者脑脊液NSE水平高于正常水平，而47%的患者血清NSE水平升高。在9例重度颅脑损伤患者中，脑脊液水平的变化反映了血清NSE水平的变化。在所有9例患者中，无论GOS预测的结果如何，血清NSE均下降至正常水平。因此，虽然NSE似乎是神经元细胞损伤的标志物，但其他标志物也必不可少。
