Alliegro M B, Dorrucci M, Pezzotti P, Rezza G, Sinicco A, Barbanera M, Castelli F, Tarantini G, Petrucci A
Centro Operativo AIDS, Istituto Superiore di Sanità, Rome, Italy.
Clin Infect Dis. 1996 Nov;23(5):990-5. doi: 10.1093/clinids/23.5.990.
A prospective study of 1,198 individuals who seroconverted to human immunodeficiency virus (HIV) was conducted to estimate the incidence and determinants of herpes zoster and to determine whether herpes zoster can accelerate the progression to AIDS. Herpes zoster was diagnosed for 48 individuals (4%). After adjusting for the CD4 cell count, individuals acquiring HIV infection through sexual contact were more likely to have herpes zoster than were injection drug users (relative hazard, 1.50). The crude relative hazard of AIDS for individuals who had herpes zoster compared with those without herpes zoster was 2.44; the adjusted relative hazard was 1.08. After adjusting for the CD4 cell count, fever was the only specific characteristic of herpes zoster that was significantly associated with a more rapid progression to AIDS (relative hazard, 6.52). Data suggest that herpes zoster occurs more frequently in individuals acquiring HIV infection through sexual transmission. There was no evidence that herpes zoster per se is an independent cofactor of progression of HIV disease, although febrile episodes of herpes zoster may predict a faster progression to AIDS.
对1198例血清转化为人类免疫缺陷病毒（HIV）的个体进行了一项前瞻性研究，以估计带状疱疹的发病率和决定因素，并确定带状疱疹是否会加速艾滋病的进展。48例个体（4%）被诊断为带状疱疹。在调整了CD4细胞计数后，通过性接触感染HIV的个体比注射吸毒者更易患带状疱疹（相对风险，1.50）。患带状疱疹的个体与未患带状疱疹的个体相比，患艾滋病的粗相对风险为2.44；调整后的相对风险为1.08。在调整了CD4细胞计数后，发热是带状疱疹唯一与艾滋病进展更快显著相关的特定特征（相对风险，6.52）。数据表明，带状疱疹在通过性传播感染HIV的个体中更频繁发生。没有证据表明带状疱疹本身是HIV疾病进展的独立协同因素，尽管带状疱疹的发热发作可能预示着更快进展为艾滋病。
