Suvisaari J, Lähteenmäki P
Steroid Research Laboratory, University of Helsinki, Finland.
Contraception. 1996 Oct;54(4):201-8. doi: 10.1016/s0010-7824(96)00189-8.
Detailed information on the menstrual bleeding patterns in users of copper-releasing intrauterine devices (IUDs) and levonorgestrel-releasing intrauterine systems (IUSs) is lacking. Even less is known about the menstrual bleeding patterns associated with postabortal insertion of IUDs. We postulated that the scarcity of IUD studies including detailed analysis of bleeding could be a result of the lack of an easy-to-use computer program designed for this purpose. We therefore developed a set of graphical user interface (Windows) programs for entering, editing, and analyzing menstrual diary data. With these programs, we reanalyzed the menstrual diaries of the subjects of one of the hospital clinics that participated in a previous multicenter study comparing copper IUDs and LNg IUSs. The group included patients who had the IUD inserted postabortally. Copper IUD users had patterns of bleeding that were stable over time, and clearly more bleeding than LNg IUS users, many of whom had either infrequent bleeding, bleeding completely replaced by regularly occurring spotting, or amenorrhea. Postabortal insertion of LNg IUSs was associated with slightly better patterns of bleeding than postmenstrual insertion. Detailed statistics on bleeding help clinicians in counseling patients regarding these methods. The statistics permit assumptions to be made about the probabilities of specific menstrual disturbances and their changes over time.
目前缺乏关于含铜宫内节育器(IUD)和左炔诺孕酮宫内节育系统(IUS)使用者月经出血模式的详细信息。对于流产后放置IUD相关的月经出血模式了解更少。我们推测,缺乏包含详细出血分析的IUD研究可能是由于缺乏为此目的设计的易于使用的计算机程序。因此,我们开发了一套图形用户界面(Windows)程序,用于输入、编辑和分析月经日记数据。利用这些程序,我们重新分析了参与先前一项比较铜IUD和左炔诺孕酮IUS的多中心研究的一家医院诊所受试者的月经日记。该组包括流产后放置IUD的患者。铜IUD使用者的出血模式随时间稳定,且明显比左炔诺孕酮IUS使用者出血更多,许多左炔诺孕酮IUS使用者要么出血不频繁,出血完全被规律性出现的点滴出血取代,要么闭经。流产后放置左炔诺孕酮IUS与比月经后放置稍好的出血模式相关。关于出血的详细统计数据有助于临床医生就这些方法向患者提供咨询。这些统计数据允许对特定月经紊乱的概率及其随时间的变化进行假设。