Versprille A, van Oosterhout M
Department of Pulmonary Diseases, Erasmus University Rotterdam, The Netherlands.
Intensive Care Med. 1996 Oct;22(10):1082-9. doi: 10.1007/BF01699232.
During alternating ventilation (AV) (i.e. differential ventilation (DV) of both lungs with a phase difference of half a ventilatory cycle) volume expansion of the inflated lung will occur partly by compression of the opposite lung.
We studied whether and how large an undulating flow would occur out of and into the non-ventilated lung during unilateral ventilation.
In 20 anaesthetized, paralysed piglets (11.0 +/- 1.0 kg) DV was applied at a rate of 10 breaths per minute (bpm). In 6 animals, 15 and 20 bpm were also applied with the tidal volume adapted no normocapnia. As the measure of interaction (cross-talk) served the volume change in the non-ventilated lung, found by integration of the low signal, in percentage of the tidal volume to the other lung.
In all pigs, tidal volume to the left lung. (VT,l = 7.33 +/- 1.06 ml kg-1) caused a volume change in the right lung of about 21% of VT,l at 10 bpm. The right-to-left cross-talk was significantly lower and about 15% of VT,r (9.07 +/- 1.21 ml kg-1). At higher ventilatory rates, the l-to-r and the r-to-l cross-talk did not change.
During unilateral ventilation, volume expansion of the inflated lung occurs partly by compression of the opposite lung. The lower mean lung volume during AV compared to synchronous differential ventilation can be explained by such compression. The mechanism of compression is similar at different ventilatory rates.
在交替通气（AV）过程中（即两肺的差异通气（DV），相差半个通气周期），充气肺的容积扩张部分是由于对侧肺的压缩。
我们研究了在单侧通气期间，未通气肺进出的波动气流是否会出现以及其大小。
对20只麻醉、麻痹的仔猪（11.0±1.0千克）以每分钟10次呼吸（bpm）的速率进行差异通气。在6只动物中，还以每分钟15次和20次呼吸的速率进行通气，并调整潮气量以维持正常碳酸血症。作为相互作用（串扰）的指标，通过积分低信号来测量未通气肺的容积变化，以占另一肺潮气量的百分比表示。
在所有猪中，左肺的潮气量（VT,l = 7.33±1.06毫升/千克）在10 bpm时导致右肺的容积变化约为VT,l的21%。从右到左的串扰明显更低，约为VT,r（9.07±1.21毫升/千克）的15%。在更高的通气速率下，从左到右和从右到左的串扰没有变化。
在单侧通气期间，充气肺的容积扩张部分是由于对侧肺的压缩。与同步差异通气相比，AV期间较低的平均肺容积可以用这种压缩来解释。在不同的通气速率下，压缩机制相似。
