Haffmans P M, Timmerman L, Hoogduin C A
Psychiatric centre Bloemendaal, The Hague, The Netherlands.
Int Clin Psychopharmacol. 1996 Sep;11(3):157-64. doi: 10.1097/00004850-199609000-00002.
In 16 depression clinics in hospitals and outpatient facilities in the Netherlands, a study was performed to evaluate and compare the efficacy and tolerability of citalopram and fluvoxamine and to determine the difference in the incidence of gastrointestinal side-effects. A total of 217 patients with a depressive disorder (DSM-III-R criteria) and a score of at least 16 on the Hamilton rating scale for depression were randomized to treatment. The results of this study indicate that the two drugs are equally effective. The adverse events occurring during treatment show a similar pattern between the two drugs, but citalopram is better tolerated than fluvoxamine. Citalopram induces fewer gastrointestinal adverse events compared with fluvoxamine. However, this did not affect the drop-out rates.
在荷兰的16家医院和门诊机构的抑郁症诊所中，开展了一项研究，以评估和比较西酞普兰和氟伏沙明的疗效及耐受性，并确定胃肠道副作用发生率的差异。共有217名符合抑郁障碍（DSM-III-R标准）且汉密尔顿抑郁评定量表得分至少为16分的患者被随机分配接受治疗。该研究结果表明，这两种药物疗效相当。治疗期间出现的不良事件在两种药物之间呈现相似模式，但西酞普兰的耐受性优于氟伏沙明。与氟伏沙明相比，西酞普兰引起的胃肠道不良事件较少。然而，这并未影响脱落率。
