Menting J E, Honig A, Verhey F R, Hartmans M, Rozendaal N, de Vet H C, van Praag H M
Department of Psychiatry and Neuropsychology, University of Limburg Maastricht, The Netherlands.
Int Clin Psychopharmacol. 1996 Sep;11(3):165-75. doi: 10.1097/00004850-199609000-00003.
A qualitative analysis of studies on the efficacy and side-effects of selective serotonin reuptake inhibitors (SSRIs) for the treatment of elderly people with depression is presented. Only placebo-controlled or comparison studies of SSRI versus other antidepressants were included. The description and methodological quality of the analysed studies were important criteria in the outcome of the analysis. Quality was assessed by means of a blinded review approach. After excluding duplicate publications, 16 studies were analysed, of which six turned out to be of good quality. The results indicated that at the end of the treatment periods (4-8 weeks) all antidepressants were equally effective. Side-effects occurred less frequently with SSRIs than with tricyclics (TCAs), and different side-effect profiles were found. Significantly fewer SSRI-treated patients than TCA-treated patients dropped out both overall and due to side-effects.
本文对选择性5-羟色胺再摄取抑制剂（SSRI）治疗老年抑郁症患者的疗效和副作用研究进行了定性分析。仅纳入了SSRI与其他抗抑郁药的安慰剂对照或对比研究。所分析研究的描述和方法学质量是分析结果的重要标准。通过盲法评审方法评估质量。在排除重复发表的文献后，分析了16项研究，其中6项质量良好。结果表明，在治疗期结束时（4至8周），所有抗抑郁药疗效相当。SSRI的副作用发生率低于三环类抗抑郁药（TCA），且发现了不同的副作用特征。总体而言以及因副作用而退出研究的SSRI治疗患者明显少于TCA治疗患者。
