Meeusen E N
Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia.
Int J Parasitol. 1996 Aug-Sep;26(8-9):813-8. doi: 10.1016/s0020-7519(96)80046-4.
Bacterial and viral vaccines have been used for several decades and have made an invaluable impact on the control of both human and animal diseases. As these vaccines are based on the induction of the "natural" protective immune response of the host, there is ample proof that this approach is effective and there is no a priori reason why a similar approach should not work for other infectious organisms, including helminth parasites. Two main stumbling blocks have so far precluded the development of effective anti-nematode vaccines: (i) the identification and isolation of the protective parasite antigens; and (ii) the induction of the appropriate protective immune effector mechanisms through vaccination. This paper will discuss the unique characteristics of nematode vaccine development and the significant progress that has been made in recent years in this area.
细菌和病毒疫苗已经使用了几十年，对控制人类和动物疾病产生了不可估量的影响。由于这些疫苗基于诱导宿主的“天然”保护性免疫反应，有充分证据表明这种方法是有效的，而且没有先验理由说明类似方法不适用于其他传染性生物，包括蠕虫寄生虫。到目前为止，有两个主要障碍阻碍了有效的抗线虫疫苗的开发：（i）保护性寄生虫抗原的鉴定和分离；（ii）通过接种疫苗诱导适当的保护性免疫效应机制。本文将讨论线虫疫苗开发的独特特征以及近年来该领域取得的重大进展。
