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硬皮病-多发性肌炎重叠综合征伴抗Ku抗体及镶边空泡形成

Scleroderma-polymyositis overlap syndrome associated with anti-Ku antibody and rimmed vacuole formation.

作者信息

Yamanishi Y, Maeda H, Katayama S, Ishioka S, Yamakido M

机构信息

Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.

出版信息

J Rheumatol. 1996 Nov;23(11):1991-4.

PMID:8923381
Abstract

Scleroderma-polymyositis overlap syndrome is strongly associated with certain autoantibodies, such as anti-PM-Scl antibody and anti-Ku antibody. We describe a case of scleroderma-polymyositis overlap syndrome associated with anti-Ku antibody, which revealed rimmed vacuole formation in addition to intranuclear and intracytoplasmic filamentous inclusions in muscle biopsy specimens.

摘要

硬皮病-多发性肌炎重叠综合征与某些自身抗体密切相关，如抗PM-Scl抗体和抗Ku抗体。我们描述了一例与抗Ku抗体相关的硬皮病-多发性肌炎重叠综合征病例，该病例在肌肉活检标本中除了有核内和胞浆内丝状包涵体外，还显示有镶边空泡形成。

相似文献

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Scleroderma-polymyositis overlap syndrome associated with anti-Ku antibody and rimmed vacuole formation.硬皮病-多发性肌炎重叠综合征伴抗Ku抗体及镶边空泡形成
J Rheumatol. 1996 Nov;23(11):1991-4.
2
A juvenile case of overlap syndrome of systemic lupus erythematosus and polymyositis, later accompanied by systemic sclerosis with the development of anti-Scl 70 and anti-Ku antibodies.一例青少年系统性红斑狼疮与多发性肌炎重叠综合征病例，后期出现抗Scl 70抗体和抗Ku抗体，并伴发系统性硬化症。
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Clinical significance of anti-Ku autoantibodies--a serologic marker of overlap syndrome?抗Ku自身抗体的临床意义——重叠综合征的血清学标志物？
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Dropped Head Syndrome and the Presence of Rimmed Vacuoles in a Muscle Biopsy in Scleroderma-polymyositis Overlap Syndrome Associated with Anti-Ku Antibody.抗Ku抗体相关的硬皮病-多发性肌炎重叠综合征中的垂头综合征及肌肉活检中边缘空泡的存在
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[Anti-Ku antibodies].[抗Ku抗体]
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Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome.从硬皮病-多发性肌炎重叠综合征患者自身抗体识别的人类自身抗原Ku（p70/p80）80-kDa亚基蛋白编码cDNA的分离与鉴定
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PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome.PM-Scl-75是多发性肌炎/硬皮病重叠综合征患者的主要自身抗原。
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[Anti-Ku antibodies].[抗Ku抗体]
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引用本文的文献

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Medicine (Baltimore). 2013 Jan;92(1):15-24. doi: 10.1097/MD.0b013e31827ebba1.
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[Inflammatory muscle diseases: dermatomyositis, polymyositis, and inclusion body myositis].[炎性肌病：皮肌炎、多发性肌炎和包涵体肌炎]
Internist (Berl). 2005 Nov;46(11):1218-32. doi: 10.1007/s00108-005-1496-4.
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Clinical evaluation of autoantibodies to a novel PM/Scl peptide antigen.
针对一种新型PM/Scl肽抗原的自身抗体的临床评估。
Arthritis Res Ther. 2005;7(3):R704-13. doi: 10.1186/ar1729. Epub 2005 Apr 1.
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Autoantibodies and overlap syndromes in autoimmune rheumatic disease.自身免疫性风湿性疾病中的自身抗体与重叠综合征。
J Clin Pathol. 2001 May;54(5):340-7. doi: 10.1136/jcp.54.5.340.