Rigon A R, Takahashi R N
Departamento de Farmacologia, CCB, Universidade Federal de Santa Catarina, Brasil.
Psychopharmacology (Berl). 1996 Oct;127(4):323-7. doi: 10.1007/s002130050093.
The present study evaluated the effects of dimethocaine and procaine, esteratic local anesthetics, on locomotor activity, conditioned place preference and on the elevated plus-maze test of anxiety in mice, behavioral tests believed to be sensitive to cocaine action. Acute administration of dimethocaine (10-40 mg/kg, IP) significantly increased locomotor activity and time spent on the drug-paired side and reduced the relative number of entries and time spent on the open arms of the plus-maze in mice. Procaine (20-50 mg/kg, IP) failed to affect these responses. These data demonstrate the locomotor stimulant, reinforcing and anxiogenic actions of dimethocaine similar to those reported for cocaine in animals. In addition, these findings support a role for dopaminergic activity, rather than local anesthetic action, in the behavioral effects caused by dimethocaine.
本研究评估了酯类局部麻醉药地美卡因和普鲁卡因对小鼠运动活性、条件性位置偏爱以及高架十字迷宫焦虑测试的影响，这些行为测试被认为对可卡因作用敏感。急性给予地美卡因（10 - 40毫克/千克，腹腔注射）可显著增加小鼠的运动活性以及在药物配对侧所花费的时间，并减少小鼠在十字迷宫开放臂上进入的相对次数和所花费的时间。普鲁卡因（20 - 50毫克/千克，腹腔注射）未能影响这些反应。这些数据证明了地美卡因具有与动物体内可卡因相似的运动刺激、强化和致焦虑作用。此外，这些发现支持多巴胺能活性而非局部麻醉作用在由地美卡因引起的行为效应中所起的作用。
