Hirschl M M, Lechleitner P, Friedrich G, Sint G, Sterz F, Binder M, Dienstl F, Laggner A N
Abteilung für Notfallmedizin, Universität Wien, Vienna, Austria.
Resuscitation. 1996 Oct;32(3):193-8. doi: 10.1016/0300-9572(96)00969-0.
We evaluated the usefulness of a rapid, qualitative, bedside immunoassay for cardiac-specific troponin T in patients with chest pain. A concordant result between quantitative troponin T and qualitative troponin T assay was observed in 183 (96%) tests. The sensitivity of the rapid troponin T assay for detecting acute myocardial infarction increased significantly according to the number of hours elapsed after onset of chest pain from 17% for patients presenting within 4 h to 71% for patients presenting in the time interval of greater than 8 h from onset of chest pain (P < 0.001). Specificity ranged from 83 to 93% in the three time intervals evaluated. A concordant result between CK-MB-measurement and rapid troponin T assay was observed in 159 (83%) tests. In 14/191 tests a positive rapid troponin T and a negative CK-MB assay was observed. In 9/14 (64%) cases this result was true positive for the rapid troponin T assay and in 5/14 (36%) cases false negative. As sensitivity and specificity of the rapid troponin T assay are comparable with CK-MB measurements, rapid troponin T assay is a simple and useful laboratory tool for the bedside triage in patients with chest pain.
我们评估了一种用于胸痛患者的快速、定性床边心肌特异性肌钙蛋白T免疫测定法的实用性。在183次（96%）检测中观察到定量肌钙蛋白T与定性肌钙蛋白T检测结果一致。快速肌钙蛋白T检测对急性心肌梗死的检测灵敏度根据胸痛发作后的小时数显著增加，从胸痛发作后4小时内就诊的患者的17%增加到胸痛发作后超过8小时就诊的患者的71%（P < 0.001）。在评估的三个时间间隔内，特异性范围为83%至93%。在159次（83%）检测中观察到CK-MB测量结果与快速肌钙蛋白T检测结果一致。在191次检测中的14次中，观察到快速肌钙蛋白T检测为阳性而CK-MB检测为阴性。在14例中的9例（64%）中，该结果对快速肌钙蛋白T检测为真阳性，在14例中的5例（36%）中为假阴性。由于快速肌钙蛋白T检测的灵敏度和特异性与CK-MB测量相当，快速肌钙蛋白T检测是胸痛患者床边分诊的一种简单且有用的实验室工具。
